Comparative study between photodynamic therapy with urucum + Led and probiotics in halitosis reduction–protocol for a controlled clinical trial

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چکیده

Background Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. aim of proposed protocol to determine whether treatment with antimicrobial photodynamic therapy (aPDT) and probiotics are effective at eliminating halitosis. Materials methods Eighty-eight patients, 18 25 years old diagnosis halitosis (H 2 S≥112 ppb, determined by gas chromatography) will randomly allocated four groups (n = 22) receive different treatments: Group 1 –treatment teeth brushing, dental floss tongue scraper; –brushing, aPDT; 3 probiotics; 4 flossing, aPDT probiotics. results halimetry compared before, immediately after, seven days thirty after treatment. microbiological analysis coated performed these same times. normality data using Shapiro-Wilk test. Data normal distribution analyzed variance (ANOVA). Non-parametric Kruskal-Wallis Wilcoxon test used analyze each evaluation periods. Clinical trail registration NCT03996044 .

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2021

ISSN: ['1932-6203']

DOI: https://doi.org/10.1371/journal.pone.0247096